Abstract: Among other layered two-dimensional (2-D) materials, transition metal dichalcogenides (TMDs) have revealed their importance in developing novel electronic devices such as field-effect transistors (FETs), optoelectronics, and biomedical sensors. The superior electrical, mechanical, and optoelectronic characteristics, in combination with naturally formed sizable and tunable bandgap of TMDs, have turned out to be promising for making new biosensors. Despite such a bright prospect, however, there remain critical scientific and technical gaps that should be addressed for advanced and practical biosensor applications:

1. .Loss of operation stability of MoS₂ FET biosensors under wet conditions
2. Lack of reusability of electronic biosensors made of TMDs
3. Absence of scalable nanofabrication methods compatible with TMDs for producing well-defined device patterns

In this talk, a series of studies will be presented, exhibiting an effort to deal with the urgent demands mentioned above. Such studies are categorized into three main topics:

1. Devise a cycle-wise method for operating MoS₂ FET biosensors integrated with a PDMS microfluidic channel, which alleviates the liquid-solution-induced issues
2. Design a new biosensor structure consisting of a bio-tunable nanoplasmonic window and a low-noise few-layer MoS₂ photodetector for achieving highly sensitive, fast, and reusable biosensor applications
3. Invent scalable nanofabrication and nanomanufacturing approaches capable of producing highly arranged TMDs device channel patterns at designated locations on a target substrate

In addition, future research opportunities that could be derived from the presented studies will be briefly introduced in this talk.