Abstract: Dr. Cetin-Atalay’s group has been working on the discovery of novel anticancer candidate molecules for epithelial cancers focusing on liver cancer. Her talk will focus on the importance of the PI3K/AKT/mTOR network for targeted cancer drug discovery. She will present two sets of molecules inducing oxidative stress and altering the PI3K/AKT/mTOR network as well as other kinase inhibitors for therapeutic strategies in liver cancer stem cells. Finally, she will discuss a novel method in computational drug discovery and its experimental validation on the PI3K/AKT signaling pathway in liver cancer cells.