Abstract: Eliu Huerta will describe ongoing efforts to bring together the Advanced Photon Source, and the Argonne Leadership Computing Facility to enable accelerated, autonomous, reliable and reproducible AI-driven discovery. He will highlight the need to automate data management by adopting practical FAIR principles which facilitate the creation, sharing and processing of AI-ready experimental datasets with edge and HPC-centric computing. Finally, will provide a vision to bring together foundation AI models, exascale computing and robotics labs to maximize the science reach of the Advanced Photon Source.