National Quantum Initiative bill passed by Congress in 2018 has led to the establishing of 5 DOE National QIS Research Centers tasked with addressing cross-cutting transformational challenges in the field of quantum information science (QIS). One of such competitively awarded centers is the Fermilab-led Superconducting Quantum Materials and Systems (SQMS) Center. Capitalizing on the foundational strength in the superconducting radio frequency (SRF) ultrahigh quality factor technology, developed originally for particle accelerators, SQMS together with its academic, industrial, and other national lab partners, is pursuing the multifold advancements in the coherence times of 2D and 3D superconducting qubits and systems, fundamental physics experiments enabled by such systems, and the associated QIS algorithms and simulation approaches. In this talk I will review the broad SQMS effort and highlight several of its key achievements, as well as the path forward.