Abstract: Semiconductors are powerful tools in electronic and photonic biointerface studies due to their ability to be configured into multifunctional devices such as sensors, modulators, and switches. We strive to develop a non-genetic solution to biological modulation at all length scales. We have developed a series of biological modulation methods based on the interaction of light with semiconductor materials and devices. Multiplexed and patterned stimulation can be implemented with high flexibility and spatial resolution without the need for excessive wiring. Several studies conducted so far have revealed how photothermal, photofaradic, and photocapacitive effects of nanostructured semiconductors can be identified, quantified, and utilized at semiconductor-based biointerfaces to modulate biological activities. These materials-based methods are non-genetic and free-standing, which overcome the limitations of current metal electrode-based devices.

My presentation will also include a few recent research findings from my laboratory. For example, I will present a nanoporous/non-porous heterojunction for improving optical modulation biointerfaces. This heterojunction is capable of non-genetic pulse stimulation of neural tissues in vivo with light intensity similar to that used in optogenetics. In addition, I will present preliminary results on the use of electrically or photoelectrochemically produced subcellular components, including extracellular vesicles and intracellular liquid condensates, for regenerative medicine in excitable tissues. At the conclusion of my talk, I will present future research in our laboratory related to biointerfaces.

Bio: Dr. Bozhi Tian received his Ph.D. degree in physical chemistry from Harvard University. He then pursued postdoctoral studies at the Massachusetts Institute of Technology in regenerative medicine and tissue engineering.