Abstract: The search for high-temperature superconductivity (HTS) and room temperature superconductivity (RTS) in hydrogen and hydrogen-rich compounds under high pressure has a long history. Recently, several reports of high Tc up to 288 K in hydrides under pressure of up to 267 GPa have appeared. The ultrahigh pressure needed to create the HTS in hydrides has hampered the detailed study of the phenomenon, as well as any potential applications. To lower the required pressure, even to zero, we have developed a pressure-quench process (PQP) and have demonstrated it successfully in stabilizing at ambient the high-pressure-induced HTS phase and other phases in FeSe and Cu-doped FeSe. It is not inconceivable that the PQP may be adapted for cuprates and hydrides with Tc approaching room temperature for science and technology. Signs of superconductivity up to 200 K appears to be evident in the POPed HBCCO samples. The results will be presented, and both the opportunities and challenges will be discussed.