Headquartered in the Knapp Center for Biomedical Discovery, and with facilities that reach across the University of Chicago and Argonne National Laboratory,The Institute for Genomics and Systems Biology (IGSB) is an engine for discovery that utilizes the latest approaches in genome analysis, high throughput screening, and biological computation. IGSB research at the University of Chicago is focused on genomics and systems biology projects to discover new mechanisms, diagnostic tools, and therapeutic targets to help improve human health, implement models to predict disease dynamics, and ascertain genomic functions that control homeostasis in living matter.