Argonne National Laboratory

Biosciences

Collaborators

Christopher S. Henry

Computational Biologist

Microbial metabolism, enzyme promiscuity

Christopher Henry’s primary research is in the field of computational biology with a focus on the prediction of phenotype from genome through the use of comparative genomics, metabolic modeling, and dynamic cellular community models.

Karolina M. Michalska

Structural Biologist

 

The primary interest of Dr. Michalska is structural biology with a focus on structure – function relationships in biochemical transformations. Currently she works on three major projects involving protein-protein complexes and large oligomeric assemblies. These include bacterial contact dependent growth inhibition (CDI) system, tryptophan synthase, and aminoacyl tRNA synthetases. She is also contributing to the structural biology of SARS-CoV-2.

Youngchang Kim

Protein Crystallographer

Hypotheticals from select pathogens

Youngchang is a structural biologist/crystallographer with an extensive background in protein purification and characterization. Youngchang is a part of NIH structural genomics programs Midwest Center for Structural Genomics (MCSG, PSI:biology, NIGMS) and Center for Structural Genomics of Infectious Diseases (CSGID, NIAID) working to build high-throughput pipeline for protein structure determination.

Gyorgy Babnigg

Bioinformatician/Molecular Biologist

Dr Gyorgy Babnigg is a bioinformatician/molecular biologist at the Biosciences Division and a senior fellow at the University of Chicago Computation Institute. He has developed several Laboratory Information Management Systems (LIMS) at the Argonne National Laboratory and managed Oracle databases for more than a decade.

Outside collaborators
  • George Phillips (Rice University) – Enzyme Discovery for Natural Product Biosynthesis
  • James Sacchettini (Texas A&M University) – Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors
  • Celia Goulding (University of California, Irvine) – Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes
  • Joshua Adkins (Battelle Pacific Northwest Laboratories) – Characterization of Secreted Effector Proteins
  • Robert Haselkorn (University of Chicago) – Transcription regulation of heterocyst differentiation
  • Howard Shuman (University of Chicago, HTRL) – Legionella secreted effectors
  • Olaf Schneewind (University of Chicago, HTRL) – Virulence factors, Yersinia pestis hypotheticals
  • Steve Kent (University of Chicago) – Racemic crystallography
  • Sean Crosson (University of Chicago) – Brucella hypotheticals
  • Michelle O’Malley (Univ. of California, Santa Barbara) – Cellulases from anaerobic gut fungi
  • Matthias Hess (University of California, Davis) – Unusual cellulases
  • Kirsten Hofmockel (Iowa State University) – Carbon cycling core enzymes in soil aggregates
  • Tilman Schirmer (University of Basel) – EAL proteins
  • Steve Winans (Cornell University) – Plant transcription factors
  • Amy Gladfelter (Dartmouth College) – RNA-binding proteins
  • John Mekalanos (Harvard Medical School) – Type VI effectors
  • Wei Zhang (Illinois Institute of Technology) – Listeria transcription factors
  • Kira Makarova (NCBI) – CRISPR proteins
  • James Shorter (University of Pennsylvania) – Hsp104 chaperone
  • Alexander Yakunin (University of Toronto) – Cas4 proteins
  • Alexander Ensminger (University of Toronto) – Legionella effectors
  • Alexei Savchenko (University of Toronto) – Legionella effectors
  • raig Roy (Yale School of Medicine) – Legionella effectors
  • Gary Stacey (University of Missouri) – Transcription factors
  • Lukasz Berlicki (Wroclaw University of Technology) – Glutamine synthetases
  • Tom Terwilliger (Los Alamos National Lab) – Essential enzymes
  • John Brumell (Hospital for Sick Children, Toronto, Canada) – Effector proteins
  • Michael E. Konkel (Washington State University) – Effector proteins
  • Francisco Barona-Gomez (LANGEBIO) – Enzyme promiscuity
  • Christine Orengo (University College London) – Human microbiome
  • Lizbeth Hedstrom (Brandeis University) – IMPDHs and their inhibitors
  • Gregory D. Cuny (University of Houston) – IMPDHs and their inhibitors
  • Yunje Cho (POSTECH, Korea) – DNA repair enzymes
  • Fraydoon Rastinejad (Sanford Burnham, FL) – Nuclear receptors
  • Theresa Koehler (The University of Texas Health Science Center at Houston) B. anthracis virulence regulator
  • Hung Ton-That (The University of Texas Health Science Center at Houston) C. diphteria sortases
  • Barbara Lipinska (The University of Gdansk) Human HtrA3 protease